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The Effects of Coffee and It’s Chlorogenic Acid in Improved Vascular Function for Prevention of Blood Vessels Related Disease Naturally

Chlorogenic acid, a major bioactive compound found in coffee may have a profound effect in stimulated vascular function in moving blood, some studies suggested.

Vascular function is the action of arteries and veins, involving blood circulation in provided nutrients and fluids to the body cells and tissue, through adjusting the blood flow.

Abnormal vascular function found in image of PR interval in electrocardiography may associate to increase risk of cardiovascular diseases(3).

Image result for Effects of Coffee

The normal of PR interval or period measured in milliseconds, is between 120 and 200ms in duration.

However, “PR-interval length, even in the conventionally normal range, is independently associated with endothelial dysfunction and increased arterial stiffness in healthy subjects free of atherosclerotic disease” said, Dr. Chan YH, the lead scientist.

According to medical literature, abnormal vascular function may increase risk of vascular disease, affecting the circulatory system in induction of peripheral artery, carotid artery and venus disease and blood clot.

The causes of abnormal vascular function are unknown. But researchers agreed that hypertension, hypercholesterolemia, smoking, diabetes mellitus, and obesity are risk factors to the onset of abnormal vascular function.

Although, there are numbers of mechanism contributed to risk of abnormal vascular function, aging is also considered as an independent risk factor, which can lead to progressive worsening of vascular function and structure.

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

According to the study lead by the University of Reading, chlorogenic acids isolated from coffee roasted bean, acutely improved vascular function, partly due to  mediation of 5-CQA, a member in the group in regulated the normal function of arteries and veins.

Chlorogenic acid (CGA) is the ester of caffeic acid and (−)-quinic acid with function in modulated lignin biosynthesis in binding to cellulose fibers and hardens and strengthened the plant cell walls.

An acute randomized, controlled, cross-over human intervention trials is conducted by researchers at the University of Reading to examine the impact of coffee intake, matched for caffeine but differing in CQA content (89, and 310 mg) on flow-mediated dilatation (FMD) in 15 healthy male subjects, in compared a second intervention trial conducted with 24 healthy male subjects.

Observation of he impacts of pure 5-caffeoylquinic acid (5-CQA), the main CGA in coffee(5-CQA; 450 mg and 900 mg) on FMD, found that
*. Low and high CGA(89 mg and 310 mg CGA) intake, show a significant effect on vascular function 1 hour after injecting coffee.

*. Coffee intake is  closely associated to the paralleled to the appearance of CGA metabolites in regulated the normal function of arteries and veins at 5 hours

*. 5-CQA (450 mg) expressed an improvement by FMD assay after 1 hour of administration.

The information  suggested that coffee has a strong effect in activated vascular function  through expression of CGA and its metabolites in plasma and numbers of other phytochemicals including 3-, 4- and 5-feruloylquinic acid and ferulic-4′-O-sulfate at 1 h and isoferulic-3′-O-glucuronide and ferulic-4′-O-sulfate.

Interestingly, in the further illustration of coffee and its CGA effect on vascular abnormality, researchers at the joint study lead by the Bioactive Substance Research Group, University of Antioquia, Medellín, Colombia, launched an investigation of participant including 38 men and 37 women with a mean ± SD age of 38.5 and body mass index of 24.1 and randomly assigned to 3 groups*  A control group that did not consume coffee or a placebo

*Group consumed 400 mL coffee/d for 8 wk containing a medium (MCCGA; 420 mg) or

*Group consumed 400 mL coffee/d for 8 wk containing a medium high  CGA content,

At the end of the experiment, researchers concluded

*. Coffee consumption over the period indicated and after 1 hours, show a significant presence of caffeic and ferulic acid concentrations in the coffee-drinking groups, with different values in 2 coffee injection group.

*  At the same time, the levels of antioxidant expression increased substantially in 2 coffee intake group, but undetectable in control group or placebo.

* All amount of antioxidants and phytochemicals creased to exist after 8 weeks.

These results indicated the efficacy of  tested acid not only has a strong implication in promoted vascular function in blood circulation but also exerted a similar function of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in decreased inflammation and prevented blood clots through its antioxidant properties.

The evidences in the study demonstrated a acute effect of coffee in promoting of vascular function in improved nutrients and fluids transportation by arteries and vessels.

Taking together, there is no doubt that coffee consumption have an enormous effect in improved vascular function in reduced risk of vascular diseases and diseases’ complications.

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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it’s news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials by Mills CE1, Flury A2, Marmet C3, Poquet L3, Rimoldi SF2, Sartori C4, Rexhaj E2, Brenner R2, Allemann Y2, Zimmermann D3, Gibson GR1, Mottram DS1, Oruna-Concha MJ1, Actis-Goretta L3, Spencer JP5.(PubMed)
(2) Coffee Consumption Increases the Antioxidant Capacity of Plasma and Has No Effect on the Lipid Profile or Vascular Function in Healthy Adults in a Randomized Controlled Trial by Agudelo-Ochoa GM1, Pulgarín-Zapata IC2, Velásquez-Rodriguez CM3, Duque-Ramírez M4, Naranjo-Cano M5, Quintero-Ortiz MM5, Lara-Guzmán OJ6, Muñoz-Durango K2.(PubMed)
(3) Abnormal vascular function in PR-interval prolongation by Chan YH1, Siu CW, Yiu KH, Li SW, Lau KK, Lam TH, Lau CP, Tse HF(PubMed)

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Border guards say Trump’s orders have IMPROVED morale and insist the immigration ban will save lives

  • National Border Patrol Council is a union which represents 16,500 border patrol agents
  • NBPC released statement on its website Sunday saying that Trump’s ‘extreme vetting’ order will save lives and money
  • Union said Trump’s policies ‘exponentially’ boosted morale among rank-and-file border patrol agents


President Donald Trump‘s executive orders on refugees was wholeheartedly endorsed Sunday by the unions representing border patrol officers and immigration and customs officials.

The National Border Patrol Council released a statement on its website Sunday praising the president’s policies as ‘swift and decisive action’ that ‘will make America safer and more prosperous.’



The statement, which was written on behalf of union members employed with the Border Patrol and the Immigration and Customs Enforcement, says that morale among officers and agents has lifted since Trump’s three executive orders were signed in his first eight days in office.

‘Morale amongst our agents and officers has increased exponentially since the signing of the orders,’ the statement read.

‘The men and women of ICE and Border Patrol will work tirelessly to keep criminals, terrorists, and public safety threats out of this country, which remains the number one target in the world – and President Trump’s actions now empower us to fulfill this life saving mission, and it will indeed save thousands of lives and billions of dollars.’

Trump on Wednesday signed two executive orders that were aimed at beginning the process of constructing a wall along the border with Mexico and denying federal funding to so-called ‘sanctuary cities’ that declined to help the government prosecute undocumented aliens, according to ABC News.

The most controversial executive order signed by the president on Friday indefinitely barred Syrian refugees from entering the US and suspended refugee admissions for 120 days.

The order also singled out citizens from Iran, Iraq, Libya, Somalia, Sudan, Syria, and Yemen, who are barred from entering the US for a period of 90 days, according to The New York Times.

Thousands of protesters (above) converged on Los Angeles International Airport on Sunday to condemn President Trump's travel restrictions as attorneys filed court papers on behalf of those who were detained at the airport

Thousands of protesters (above) converged on Los Angeles International Airport on Sunday to condemn President Trump’s travel restrictions as attorneys filed court papers on behalf of those who were detained at the airport

But the order appears to trigger widespread confusion among government agencies who began detaining green card holders and permanent residents from these countries even though they have been living here for years.

The detentions and deportations of a number of immigrants ignited anger and protests at airports and cities across the country over the weekend.

The traditionally apolitical NBPC took the unprecedented step of endorsing Trump for president during the campaign, according to The Washington Times.

That decision, however, was made by the union’s leadership board that is comprised of 11 members. The union as a whole represents 16,500 agents, according to The Los Angeles Times.

'Morale amongst our agents and officers has increased exponentially since the signing of the orders,' the statement from the National Border Patrol Council read on Sunday. Above an agent patrols the border fence that divides the US and Mexico in the town of Nogales, Arizona

‘Morale amongst our agents and officers has increased exponentially since the signing of the orders,’ the statement from the National Border Patrol Council read on Sunday. Above an agent patrols the border fence that divides the US and Mexico in the town of Nogales, Arizona

Trump issued his most substantial defense of his ‘extreme vetting’ executive order on Sunday afternoon, saying in a statement from the White House that he’s not banning Muslims from entering the US – and laying much of the grief at former president Barack Obama’s feet.

‘My policy is similar to what President Obama did in 2011 when he banned visas for refugees from Iraq for six months,’ Trump said of his own order, which is slated to expire in 90 days.

And he said that the seven nations targeted by his executive order ‘are the same countries previously identified by the Obama administration as sources of terror.’

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