Avocado may be the generation whole fruit medicine for the prevention and treatment of prostate cancer with no side effects, some scientists found
Prostate cancer is a medical condition in which the cells of the prostate has become cancerous, causing abnormal cells growth.
Most prostate cancers are slow growing and can be detected during the physical (rectum) exams.
Most cases of prostate cancer start in the cell on the surface of the inner lining of the prostate tissues.
At the advanced stage, as the tumor continues to grow, it may suppress the nearly healthy tissue and nerve cells leading to severe symptoms and pain.
According to the statistic provided by the American Cancer Society, 1 in 9 men will be diagnosed with prostate cancer during his lifetime. Approximately, 6 cases in 10 are diagnosed in men aged 65 or older.
Most common symptoms of prostate cancer include frequent urination, weak or interrupted urine flow or the need to strain to empty the bladder. and the urge to urine frequently at night due to the large size of the tumor that suppresses the bladder and the flow of urine.
Some patients may also experience symptoms blood in the urine, blood in the seminal fluid and pain or burning during urination caused by the tumor that breaks the nearby small veins and nerve cells.
At this stage, cancerous cells from the prostate gland can also travel a distance away to infect other healthy tissue and organ, leading to the secondary metastasis.
There are many risk factors associated with the onset of prostate cancer. However, the increase in age, location and behavioral correlates are some prevalent risk of the disease onset.
According to the University of Zurich, factors that may enhance prostate cancer risk include frequent consumption of dairy products and, possibly, meat and increased physical activity, intakes of tomatoes, cruciferous vegetables, and soy are possible preventative behavioral factors.
These results indicated that by following a healthy diet with moderate exercise, the risk of prostate cancer can be reduced substantially.
Avocado is commercially valuable fruit cultivated in tropical climates throughout the world. It is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
With an aim to discover a natural ingredient or whole food for the prevention and treatment of prostate cancer with no side effects, researchers at the University of the West Indies investigate the intake of dietary MUFAs from whole fruit of avocado in the risk of prostate cancer (PCa).
The case study included 209 men 40-80 years old with newly diagnosed, histologically confirmed prostate cancer and 226 cancer-free men, attending the same urology clinics.
Higher intakes of dietary MUFA were inversely related to prostate cancer. The principal source of dietary MUFA of the participants was avocado intake. Dietary intakes of other fats were not associated with PCa.
Dr. Jackson MD, the lead author wrote in the report, “Whole-blood and dietary MUFA reduced the risk of prostate cancer. The association may be related to avocado intakes”.
Researchers at the University of California agreed that the avocado is known as a rich source of monounsaturated fatty acids, for treatment of prostate cancer, but suggested that other bioactive substances including carotenoids, which might contribute to cancer preventive properties similar to those attributed to other fruits and vegetables.
In vitro, injection of acetone extract of avocado containing carotenoids and tocopherols inhibited the growth of both androgen-dependent (LNCaP) and androgen-independent (PC-3) prostate cancer cell lines.
Incubation of PC-3 cells with the avocado extract led to G(2)/M cell cycle arrest accompanied by an increase in p27 protein expression, a protein that regulates the cell cycle.
Lutein combined with other bioactive compounds also exerted a similar effect in inhibiting the prostate cancer cell spreading, but the chemical compound alone did not reproduce the effects of the avocado extract on cancer cell proliferation.
These result strongly indicated, the avocado anti-prostate cancer efficacy probably is associated with all bioactive compounds containing in the fruit such as monounsaturated fat, and carotenoids.
In order to illustrate the importance of the whole fruit in the inhibition of prostate cancer, researchers examined the 3 newly isolated compounds from unripe avocado, and found that all 3 compounds exert significant activity against six human tumor cell lines in culture and show selectivity for human prostate adenocarcinoma (PC-3) cells with 3 being nearly as potent as adriamycin.
Dr. Lu QY, after taking into account other factors said, “Because the avocado also contains a significant amount of monounsaturated fat, these bioactive carotenoids are likely to be absorbed into the bloodstream, where in combination with other diet-derived phytochemicals they may contribute to the significant cancer risk reduction associated with a diet of fruits and vegetables”.
Taken altogether, avocado with abundant bioactive active compounds and MUFAs may be considered a functional fruit for the prevention and treatment of prostate cancer, pending to the confirmation of large sample size and multicenter human study.
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